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Archive for August, 2009


CDC recommends Asian, African immigrants be tested for hepatitis B

According to creative guidelines CDC officials made public on Thursday, people born in either Asia or Africa who currently be in the U.S. should be tested in the interest of hepatitis B, the San Francisco Chronicle reports.

Other “at-risk” groups, such as injection drug users and men who have sex with men, also should be tested, the guidelines say. The announcement was made during a news conference at the San Francisco-based Chinatown Public Health Center.


While previous guidelines have focused on screening and testing, the new guidelines focus on treatment, education and the long-term care of those with the disease, the Chronicle reports.


San Francisco is a “gateway for immigrants from China and other Asian countries” that have a high hepatitis B prevalence, and the city also has the nation’s highest rate of liver cancer, according to the Chronicle. The disease affects an estimated 25,000 Asian-Americans/Pacific Islanders in the city. Nationwide, one in 12 Asian-Americans/Pacific Islanders has hepatitis B, according to CDC. The city also was chosen in part because of the success of a hepatitis B awareness campaign, which has vaccinated 4,000 residents since April 2007.


State Assembly member Fiona Ma (D), who was diagnosed with hepatitis B at age 22, said, “Our culture is not to talk about disease. People should not keep this a secret,” adding, “I was walking around for 20 years not knowing what to do about my own health. I have a one in four probability of developing liver cancer. I’m hopeful that the disease won’t affect me in my lifetime” (Fernandez, San Francisco Chronicle, 9/19).

This article is republished with kind permission from our friends at The Kaiser Family Foundation. You can view the entire Kaiser Daily Health Policy Report, search the archives, or sign up for email delivery of in-depth coverage of health policy developments, debates and discussions. The Kaiser Daily Health Policy Report is published for Kaisernetwork.org, a free service of The Henry J. Kaiser Family Foundation. Copyright 2008 Advisory Board Company and Kaiser Family Foundation. All rights reserved.

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A stem cell type supposed to be crucial for angiogenesis and cancer growth does not exist?

Recent Articles on Medical: Vitaminas para prevenir la impotencia sexual.

It is considerably believed that tumor angiogenesis and cancer lump critically depend on circulating endothelial precursor cells, mobilized from the bone marrow. The recent learning from researchers at the University of Helsinki, Finland, and Stanford University, US, at the moment suggests that a stem cell type meant to be crucial for blood vessel formation and cancer growth does not actually endure.

Angiogenesis, the growth of new blood vessels, is a central process in diverse physiological and pathological situations such as healing of wounds and traumas, cardiovascular disorders, inflammatory conditions such as rheumatoid arthritis, and in cancer growth. The current belief about the source of blood vessel wall endothelial cells (ECs) responsible for vascular growth in adults is that a significant and crucial part of neovascular ECs originate from circulating stem and progenitor cells that are first mobilized from the bone marrow (BM), and subsequently differentiate to mature bona fide ECs and incorporate in the vasculature. This concept has become textbook material, and a common theme in modem vascular and cancer biology.


Importantly, it is widely believed that tumor angiogenesis and cancer growth critically depend on BM derived circulating endothelial precursor cells. Endothelial precursors would thus provide a powerful novel approach to block tumor angiogenesis and cure cancer. Correspondingly, therapeutic transplantation of such stem cells would be a promising approach to restore tissue vascularization after ischemic events. Clinical trials with human patients are currently ongoing based on the circulating endothelial precursor cell dogma.


Now, researchers lead by Dr. Petri Salvén at the University of Helsinki, Finland, and the stem cell research pioneer Dr. Irving Weissman at Stanford University, California, have shown that circulating endothelial precursor cells actually do not exist, and that angiogenesis and cancer growth do not involve or depend on such hypothetical stem cells. (PNAS, in press; online 21.-25.4.). By using endothelial cell specific genomic mouse models and most modern three dimensional cellular imaging technologies, they show that endothelial differentiation is not a typical function of BM derived stem cells, and it has to be an extremely rare event if it occurs at all. However, angiogenic and tumor tissues contain large numbers of BM derived cells such as ordinary white blood cells that often are very close to blood vessel walls, and may therefore have been misinterpreted as blood vessel wall ECs in earlier studies utilizing less advanced technologies.


The results have great practical significance when researchers are trying to focus on novel approaches to cure cancer by targeting the normal cells of the body which supply tumors with blood and nutrients. “Our results will help the researchers to concentrate their efforts on molecular and cellular targets that actually exist” says Dr. Salvén, leader of the Helsinki team.


“It has been a learning experience to try to publish results that demonstrate that a number of fellow research have for years been studying nonexistent cells”, Dr. Salven comments. “Issues concerning publication bias and nonaccessibility of negative data are really becoming more and more relevant, just as recently seen also in other fields of biomedicine.


http://www.helsinki.fi/university/

Diabetes Patients With High Triglycerides And Low HDL Cholesterol Get The Most Benefit From Fenofibrate Treatment: New Data From The FIELD Study

Fenofibrate treatment reduces cardiovascular disease (CVD) peril (defined by utter cardiovascular events: the composite of cardiovascular downfall, myocardial infarction, stroke, and coronary and carotid revascularization) in patients with type 2 diabetes and atherogenic dyslipidemia, that is, the emulsion of high triglyceride (2.3 mmol/L-200mg/dL or higher) and low high-density lipoprotein (HDL) cholesterol (

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Obesity Rates Among American Women Falling

While more and more children and adult males are becoming obese in the USA, rates seeking women appearance of to be falling. 33.2% of American women were obese in 2004, a slight drop from 33.4% in 2000. This is the first bit of encouraging news Dialect anenst despite the ever-increasing weight of Americans in general over the model twenty years.

Healthcare professionals in the USA say this offers a glimmer of hope. If women take healthier lifestyles, this could done be passed on to other members of the group.

Unfortunately, men and children are putting on the weight faster than women are losing it.

Why are women bucking the incline?

There could be diverse reasons. Here are some opinions we received from health care professionals and members of the patrons:

– Women be prone to seek skilled lift more than men do (for health).

– Compliance is better entirety women (women are better at following instructions, either on a label, or from the people they went to see to a healthiness problem).

– More literature aimed at women (women’s magazines) offer utilitarian advice on weight management and inexact health, in comparability to handbills aimed at men.

– Women have mature better au fait about health and nutrition than men (related to the previous point).

– This surprising slight depart in obesity levels among women could just be a blip.

– Women are more upset about how they look than men are.

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Written by: Christian Nordqvist
Columnist: Medical News Today

Copyright: Medical Front-page news Today

Not to be reproduced without permission of Medical Account Today

Medicare Rights Center Recruits for Consumer Action Board

Board Members to Inform on Local Health Care Access and Affordability Concerns -

Uncharted York - The Medicare Rights Center (MRC) is now recruiting people with Medicare who prerequisite to scram a difference in local,
federal, and national health control policy in compensation a National Medicare Consumer Action Board (CAB).

The Consumer Sortie Board brings the articulation of consumers into the trim attention consideration. The board is currently comprised of 52
older adults and people with disabilities who have Medicare from 34 states, and require lengthen past the next year to focus on
policies affecting health care access and affordability.

“The consumer voice is frequently the pattern turn heard in the national health mindfulness debate,” said Robert M. Hayes, president
of the Medicare Rights Center. “We propose to transformation that.”

Consumer Action Advisers aboard members work in partnership with MRC staff to dealing information on Medicare issues and develop
practice positions in the service of communities, the media, and elected officials. By regular teleconferences, the members notify MRC,
a national, not-for-profit consumer service group, on emerging robustness meticulousness concerns in their communities. Each CAB member
coordinates outreach and direct act efforts, including testifying at universal hearings and book letters to limited papers.
CAB members also running state-specific inquire into, identify Medicare consumer forums, and partner with local senior and health
anxiety advocacy groups.

CAB members comprise a dissimilar group, representing retirees from a miscellany of fields including teaching, health care, labor
organizing, and the arts. Less all are active members of community-based groups.

Interested applicants must have Medicare and should e-mail CAB Coordinator Ross Kessler at rkessler@medicarerights.org recompense
additional poop. This is a volunteer situate.

http://www.medicarerights.org

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The American Red Cross Helps Build New Community For Tsunami Survivors In The Maldives

Four years after the devastating Indian Ocean Tsunami displaced millions of people, the American Red Cross is relocating families who lost their homes to a newly built community in the Maldives.

In the aftermath of the tsunami, 3,600 people were left homeless on the cay of Kandolhudhoo and sent to evanescent camps on five neighboring islands. Instead of rebuilding the infrastructure on their former island, the government of Maldives determined the -away-trackless island of Dhuvaafaru would be a safer alternative for the population because it is more protected from days tsunamis. The domination turned to the American Red Cross and International Federation of Red Cross and Red Lunette Societies to prosper the relocation possible.

“Dhuvaafaru is one example of our long-regarding commitment to confirm communities rebuild in a sustainable way and are changed for future disasters,” says Gerald Anderson, Senior Director of the American Red Cross Tsunami Recovery Program. “With our frame, resident residents are nowadays capable to resume their daily lives and start planning for the subsequent.”

With American Red Blend economic sponsor, construction teams built 600 houses, a preschool, a primary and supportive school, an auditorium, an administration building, roads, an electrical grid, a sewer and waste system and a rainwater collection system. Parts of the island were also raised to provide safe areas through despite families during future disasters.

In early December, the antediluvian residents of Kandolhudhoo completed a housing raffle and are relocating to Dhuvaafaru later this month.

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“The first discipline year on Dhuvaafaru begins in February,” says Dan Curtiss, Head of Duty for the American Red Cross in the Maldives. “Thanks to this project, generations of children can now grow up in a safer, more prepared community.”

The American Red Cross improvement work spans much broader than helping rebuild communities in the Maldives. From providing women with microfinance loans to start remodelled businesses in Indonesia, to teaching children normal hygiene techniques in Sri Lanka, and supplying villages with admit salt water and precise sanitation in Thailand, communities affected by the 2004 tsunami are graciously on their velocity to a full recovery and the American Red Furious is more committed than ever to see it happen.

As part of the world’s largest humanitarian network, the American Red Cross alleviates the suffering of victims of war, disaster and other international crises, and works with other Red Cross and Red Lunette societies to improve long-standing, life-threatening conditions in developing nations. We reconnect families separated by emergencies and educate the American public in international humanitarian law. This help is made possible from head to foot the generosity of the American universal.

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Extension of Australia’s Medicare safety net will ease the financial burden on pregnant women

Australian Medical Association President, Dr Bill Glasson, said yesterday that the Government’s outcome to offer the Medicare safeness net to cover out-of-hospital secluded obstetrics services would ease the fiscal saddle with on pregnant women and their families.

Dr Glasson said the introduction of the Medicare safety net earlier this year covered women accessing IVF services but did not extend to gap payments for pregnancy.


“Women who are patients of private obstetricians have been paying high gap payments without access to Medicare or private health insurance benefits,� Dr Glasson said.


“By creating a new Medicare item number to cover a proportion of the gap payments for the planning and management of a pregnancy the Government has taken some of the worry out of pregnancy for many women.


“The AMA welcomes this initiative, which follows close consultation between the Government and the medical profession.


“The real winners are the patients who will now receive greater coverage under the Medicare safety net.


“The AMA will work with the Government to ensure the measure is implemented with the full co-operation of the profession in a way that is of most benefit to patients,� Dr Glasson said.


http://www.ama.com.au

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Some brains wired to encourage fidgeting

Some brains may be wired to support fidgeting and other uptight behaviors that consume calories and serve control weight, according to new research published by The American Physiological Camaraderie.

The study found that the brains of rats bred to be lean are more sensitive to a chemical produced in the brain, orexin A, which stimulates appetite and spontaneous physical activity such as fidgeting and other unconscious movements. Compared to rats bred to be obese, the lean rats had a far greater expression of orexin receptors in the hypothalamus.


“The greater expression of orexin receptors suggests the lean rats’ brains were more sensitive to the orexin the brain produces,” said Catherine M. Kotz, the study’s senior researcher. “The results point to a biological basis for being a couch potato.”


This line of research suggests that frequent minor unconscious movements such as fidgeting and other behaviors associated with restlessness burn calories and help control weight, Kotz said. Further, it suggests a strategy to reduce weight gain and could lead to the development of a drug to stimulate minor activity.


The study “Elevated hypothalamic orexin signaling, sensitivity to orexin A and spontaneous physical activity in obesity resistant rats,” appears in the online edition of the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology published by The American Physiological Society. The study was done by Jennifer A. Teske and Allen S. Levine of the University of Minnesota and the Minnesota Obesity Center, St. Paul; Michael Kuskowski, VA Medical Center, Minneapolis; James A. Levine, Mayo Clinic, Rochester, Minnesota; and Catherine M. Kotz, the VA Medical Center, University of Minnesota, and the Minnesota Obesity Center.


“Many people focus on diet, but it may be more feasible for some people to stand or move more throughout the day” as a way to control their weight, Kotz said. Contrary to common belief, metabolism rates don’t vary greatly from person to person and weight gain usually results from eating too much, burning too few calories, or both, she said.


The researchers drew their conclusions after performing a series of experiments with obesity-prone and obesity-resistant rats. The obesity-prone strain was developed for obesity research by breeding obese rats with other obese rats. The obesity-resistant rats were developed by breeding lean rats with lean rats, Kotz noted. The study also employed a control group of normal laboratory rats.


Each rat consumed the same number of calories each day. The researchers took baseline measurements of each rat’s activity using sensors to measure even minor movements, such as grooming and standing.


They found that the lean group moved significantly more during this baseline period than the obese group, Kotz said. This was true even though the rats were young and both groups weighed the same — eliminating the obesity itself as the cause of the decreased movement. After the baseline data gathering, the researchers moved to the experimental part of the study.


“We knew from previous studies that orexin stimulated physical activity, and so we wanted to find out whether it enhances activity more in lean rats than in obese rats, Kotz explained. The researchers injected orexin into the lateral hypothalamus area of the brains of both groups and found that the lean rats became even more active, while the obese rats didn’t respond much at all. “Not only do the lean rats have a higher base activity rate but they respond more to orexin,” she said.


Orexin must bind to receptors in the brain to produce increased activity, so the researchers reasoned that the lean rats must have more orexin receptors. When they did a blind analysis of the brains of obese and lean rats of various ages, they found that the lean rats had double the gene expression level of orexin receptors compared to the obese rats, Kotz explained.


The greater gene expression of orexin receptors does not conclusively prove that there are more orexin receptors, but it is highly suggestive of that finding. Kotz and her fellow researchers are now looking to see if the lean rats have a greater number of orexin receptors in their brains.


Because the rats in this study ate the same amount of food, the researchers concluded that the weight gain of the obese rats comes more from expending too few calories than from consuming too many. Other studies have shown that disabling the orexin system of lean rats causes them to eat less and move less, which leads them to become obese, Kotz said. When the orexin system is working optimally, the increase in eating which orexin causes is believed to be offset by increased physical activity, she said.

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It would be impossible to do a similar study of the brain in humans. But one of the researchers, James Levine, found in a previous study with humans that lean individuals move about two hours per day more than obese individuals. What does this mean for those who are overweight?


“If we can get obese individuals to a slightly higher level of activity, that would be very beneficial,” Kotz concluded.


http://www.the-aps.org

Coffee May Protect Against Breast Cancer

Depending on which variant of a inevitable gene a strife has, a coffee consumption rate of at least two-three cups a day can either downgrade the total risk of developing teat cancer or delay the onset of cancer. This is shown in stylish probe from Lund University and Malmo University in Sweden.

The effect of coffee is related to estrogens, female making love hormones. Certain metabolic products of these hormones are known to be carcinogenic, and various components of coffee can modify the metabolism so that a woman acquires a punter configuration of various estrogens. What’s more, coffee contains caffeine, which also hampers the growth of cancer cells.

The cancer researcher Helena Jernstrom and her associates have studied the coffee-drinking habits of nearly 460 mamma cancer patients being treated in Lund. The results show that the effect of coffee varies depending on which variant the women deceive of a gene called CYP1A2, which codes because an enzyme that metabolizes both estrogen and coffee. Half of the women had a variant called A/A, while the others had either A/C or C/C.

“Those women who had one of the C variants, and who had delirious at least three cups of coffee a day, developed breast cancer considerably more seldom than women with the A/A changing with the same coffee consumption. Their cancer peril was only two thirds of that of the other women.

A/A women who had drunk two or more cups of coffee a era received more ambiguous resist from their coffee consumption. On the one-liner hand, their cancer appeared considerably later than magnitude women who had rarely or under no circumstances inspirited coffee at a finances age of 58 years as a substitute for of 48 years, unless they had taken hormone replacement therapy for menopausal symptoms, says Helena Jernstrom.. On the other hand, nearly 15 percent of these women had estrogen-insensitive (ER negative) tumors, which are more ill-behaved to gift.

“The the better nevertheless had estrogen-sensitive and more readily treated tumors. And women who expand breast cancer at a higher time often do more intelligent than those who into the possession of it earlier in time,” says Helena Jernström.

She stresses, however, that it is too early to make any dietary recommendations with regard to coffee consumption.

“This is inexperienced information that needs to be corroborated in other studies rather than we can issue any recommendations. If coffee does in fact stipulate some protection against bosom cancer, then women in such a coffee-drinking country as Sweden ought to demand fewer cases of cancer than other countries. This is also the package, at least compared with the U.S. There the fit of breast cancer cases in the population is considerably higher, and there people drink both more decaffeinated coffee and less coffee in common.”

These examination findings are published in the journal Cancer Epidemiology, Biomarkers and Prevention, with doctoral trainee Erika Bageman as margin prime mover.

Vetenskapsradet (The Swedish Experimentation Council)
http://www.vr.se

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Chimp Receives Surgery From A UK Orthopedic Surgeon To Correct A Deformity

An orthopaedic surgeon at the University of Liverpool has performed a groundbreaking operation on a chimp in Cameroon to decorous a deformity more commonly seen in dogs.

The three year-beloved chimp called Janet was rescued from the Cameroon pet trade model year and now lives in a chimpanzee reserve supported by the Cameroon Wildlife Aid Fund. Janet was powerless to climb and had difficulty walking because a bone in her forearm - the ulna - had stopped growing.

It is idea that her modify, known as angular limb deformity, is a congenital problem, but could also have been caused or aggravated by being chained at the wrist by traders. This forced the arm’s radius to increase in a circular manner making her arm coolly perverse. Vets have seen the deformity in dogs before but never in chimpanzees and were called in to assess Janet’s condition.

Rip off Pettitt, orthopaedic surgeon at the University’s Small Animal Teaching Convalescent home, said: “Surgery to correct the modify in dogs is less complex than the procedure in chimps. In dogs bone network stops growing at in life, so once the limb is straightened there is little time since the deformity to recur and kibitz with bone development. In chimps and humans however, the areas of spread at the end of great bones can freeze open concerning years, so there is loads of time for the condition to re-emergence. We therefore sought the advice of specialists at Robert Jones and Agnes Scour orthopaedic hospital at Oswestry - to make sure we protected any growth left in Janet’s limb.

“The earliest step was to undo the far stop of the ulna, which had befit compacted adequate to the continued wart of the radius. A 14mm triangular section of bone was then removed from the radius in order to straighten the limb and a bone plate was inserted into the radius to obvious the two ends of the bone.”

Selling chimps as pets is illegal but rife on the black market in Cameroon. Of age chimpanzees are slaughtered for their meat and the young chimps are then bewitched away and sold as pets.

Rachel Hogan, manager of the chimpanzee reserve in Cameroon, said: “Janet is recovering grammatically and has up to date rejoined her group at the reserve. She has been undergoing physiotherapy so that she can learn how to work the limb suitably. She is made to grip a ball a hardly times a day and cancel cut off tops to exercise her wrist. The X-rays show the surgery was a ended success.”

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Article adapted by Medical News Today from novel press report.
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1. Suited for more intelligence about the chimpanzee reserve log onto the Cameroon Wildlife Grant-in-aid Fund’s website at: http://www.cwaf.org/index.html

2. The University of Liverpool is a member of the Russell Group of best research-intensive institutions in the UK. It attracts collaborative and contract research commissions from a wide range of national and international organisations valued at more than £108 million annually.

Begetter: Samantha Martin

University of Liverpool

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